Association Between Toxoplasmosis Infection and Human Insulin In Pregnant and Aborted Women

Abstract

Background : People with compromised immune systems are more likely to get infected with the opportunistic parasite Toxoplasma gondii than healthy individuals. Diabetes and toxoplasmosis are two conditions that are rather prevalent in Iraq.

Objective : human insulin was the major objective of this study, along with determining the frequency of anti- T. gondii IgG antibodies in pregnant and abortion. In addition to this, establish a connection of (RBS) and (HbA1c).

Methods : The investigation was in Al-Qadisiyah. The term for collecting was from the November 2022 to the  end of February 2023. where specimens were collected from the Maternity and Children's Teaching Hospital, 350 serum samples that were collected from pregnant, and abortion women. The healthy samples that served as a control group50 samples,. Both the ELISA technique and the Toxo Rapid Diagnostic Test (Cassette) were used to analyze the samples in order to determine the levels of human insulin present in pregnant and abortion women. Also measures (HbA1c) and (RBS).

Results : the Results According Cassette the 350 samples, only 130 (43.3%) positive, whereas 170 (56.7%) negative. Using ELISA, anti-T. gondii IgG was present in 90 (69.2%) of the women from 170 positive cassette. ELISA was also used to assess of human insulin that was present in order to get a better understanding of the role that toxoplasmosis plays in the development of diabetes. Patients with diabetes had considerably higher levels of human insulin (22.83 ± 13.91) when compared to patients with toxoplasmosis alone and healthy controls

Conclusion : T. gondii is more prevalent among pregnant women and abortions. Diabetes and toxoplasmosis have been shown to have a close connection, according to research. Our hypothesis is that toxoplasmosis provides the way for diabetes, and diabetes paves the way for toxoplasmosis. Toxoplasmosis is more likely to develop in people with diabetes since the disease lowers the immune response.