Investigation of some chemotherapy drugs induce cardiotoxicity

Authors

  • Asia A. Mahdi Department of Forensic Biology, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq.
  • Basma H. Bedair Department of Experimental Therapy, Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.
  • Ashjan M. Hussein Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.
  • Alyaa K. Abood Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.
  • Rabiah M. Sabri Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.
  • Shams A. Mohammed Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.
  • Eman G. Metaab Iraqi Center for Cancer Research and Medical Genetics, Mustansiriyah University, Baghdad, Iraq.
  • Reem H. Al-Tabra Department of Forensic Biology, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq.
  • Nada H. Bedair Department of Forensic Engineering, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq.
  • Moustafa A. Gouda Department of Chemistry, College of Science, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia.
  • Asmaa A. Jawad Department of Chemistry, Higher Institute of Forensic Sciences, Al-Nahrain University, Baghdad, Iraq.
  • Abbas K. Abbas Muthana Agriculture Directorate, Ministry of Agriculture, Al-Muthana, Iraq.

DOI:

https://doi.org/10.55145/ajbms.2025.04.02.001

Keywords:

Cardiotoxicity; Chemotherapy; Heart failure; Cardio protection; CTIC

Abstract

The risk of long-term cardiovascular problems resulting from cancer treatment is rising due to the growing population of cancer patients. Cancer therapy-induced cardiotoxicity (CTIC) is a partially elucidated consequence of diverse chemotherapeutic drugs, targeted anti-cancer treatments, and radiation treatment. It is usually identified clinically by a decrease in left ventricular ejection fraction, evaluated by echocardiography. Nonetheless, the emergence of cardiac functional decline signifies irreparable heart injury, underscoring the need for the development of diagnostics capable of identifying CTIC before the commencement of functional deterioration. Growing evidence indicates that abnormal changes in heart metabolism significantly contribute to the onset of CTIC. The treatment progress has significantly enhanced the recovery rate of cancer patients. This better longevity is concomitant with increased risks for cardiovascular complications. Chemotherapy-induced cardiotoxicity is a perilous outcome that limits the therapeutic use of various chemotherapy agents. This review analyses the prevalence of heart disease is caused by immunotherapeutic medicines and chemotherapy. The preventive characteristics of antioxidants and future possible concerns about cardiotoxicities caused by treatment are the primary topics of discussion in this study.

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Published

2025-08-23

How to Cite

Mahdi, A. A., Bedair, B. H., Hussein, A. M., Abood, A. K., Sabri, R. M., Mohammed, S. A., … Abbas, A. K. (2025). Investigation of some chemotherapy drugs induce cardiotoxicity. Al-Salam Journal for Medical Science, 4(2), 1–10. https://doi.org/10.55145/ajbms.2025.04.02.001

Issue

Vol. 4 No. 2 (2025)

Section

Articles

License

Copyright (c) 2025 Asia A. Mahdi, Basma H. Bedair, Ashjan M. Hussein, Alyaa K. Abood, Rabiah M. Sabri, Shams A. Mohammed, Eman G. Metaab, Reem H. Al-Tabra, Nada H. Bedair, Moustafa A. Gouda, Asmaa A. Jawad, Abbas K. Abbas

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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