A An Updated Evaluation of the Link Between Helicobacter pylori and Colorectal cancer

Abstract

The Gram-negative bacterium Helicobacter pylori (H. pylori) is linked to gastric disorders such as gastritis, peptic ulcers, and stomach cancer. There may be a link between H. pylori infection and the risk of extra gastric illnesses, such as colorectal cancer, according to new research. the current knowledge of the virulence factors and the relationship between H. pylori infection and colorectal cancer. Studies indicate that H. pylori infection may affect colorectal carcinogenesis by indirect effects on systemic inflammation, hormonal changes, or direct effects via bacterial translocation, while the precise mechanisms behind this link remain unclear. Some epidemiological studies have reported a positive association between H. pylori infection and the risk of colorectal cancer or adenomas, although results are inconsistent. Further research is needed to clarify the nature of this association, understand the underlying mechanisms, and determine the potential implications for colorectal cancer prevention and management.