Correlations between CEA, CA19-9, CA125 and clinical stage among breast cancer group

Abstract

Breast cancer was and remains the most common type of cancer among women worldwide, thus finding dependable biomarkers for diagnosis, prognosis, and surveillance is imperative, and this study explores its relationship to the clinical pathological characteristics of patients with breast cancer.220 women include 120 with breast cancer and 100 healthy controls, their age between 17 to 63 years, participated in a cross-sectional observational study. The presence of metastases, tumor stage, and histological grade were all correlated with serum levels of CEA, CA19-9, and CA125 from many types of breast cancer invasive ductal carcinoma, Marker levels increased progressively with advancing clinical stages and histological grades. CEA and CA125 were particularly associated with higher tumor grade and advanced disease stage, while CA19-9 showed a moderate association. Higher CEA, CA19-9, and CA125 blood levels are strongly linked to more advanced stages and aggressive histological grades of breast cancer. Although more validation is required to validate their specificity and clinical relevance, these indicators may be used as supplemental tools in the prognostic assessment and clinical management of breast cancer.